Research in the Macoska Laboratory seeks to elucidate the role of paracrine interactions between epithelial and associated stromal cells in the etiology of benign and malignant proliferative disease in the prostate.  One aspect of this research is to define the specific signaling mechanisms in epithelial cells that are activated or inactivated by stromal-secreted proteins. Another aspect is to determine how growth factors secreted by aging stromal fibroblasts stimulate epithelial cell proliferation and motility.

This link will take you to the offical Macoska Laboratory website at the University of Michigan:

http://sitemaker.umich.edu/macoskalaboratory/home